The long-term goal of this project is to strengthen regional innovation systems, enhance innovation capacities, and promote regional development in the United States. The objective of the proposal is to create quantitative, comprehensive, and systemic regional innovation measures which highlight gaps in regional innovation assets, resource endowments and commitments, and policy options that motivate, align, and leverage regional assets, build up integrated and coherent regional innovation systems, and achieve regional prosperity. This research is also intended to identify regions, competitors or peers, with similar regional asset endowments and gaps yet different development prospects for future road trips of regional leaders and stakeholders and for related comparative case studies to shed light on shared and tailored development strategies.